Removing UPD's from Session Collection (2016)

Has anyone ever removed UPD's from a Terminal Services Session Collection (2016) before?

I've tested removing the setting in my dev environment and that new users don't get a UPD and existing users no longer mount theirs at login. Besides the obviously profile data now missing, are there any traps that are not obvious?

I have already enabled folder redirection so all users files and folders will remain (outside of appdata), I'm considering moving to FSLogix, anyone else moved from UPD to FSLogix?

https://docs.microsoft.com/en-us/fslogix/install-ht

Our reason is that our AV and security suite keep locking the UPD's after a user logs out and changing our suite is not possible at this point in time.

Thanks

Craig